Evidence for Metabolic Hypothalamo-Amygdala Dysfunction in Narcolepsy
نویسندگان
چکیده
منابع مشابه
Reduced amygdala activity during aversive conditioning in human narcolepsy.
Narcolepsy with cataplexy is a sleep-wake disorder caused by a loss of hypothalamic hypocretins. Here we assessed the time course of amygdala activation during aversive conditioning in unmedicated patients with narcolepsy. Unlike healthy matched control subjects, narcolepsy patients had no enhancement of amygdala response to conditioned stimuli and no increase in functional coupling between the...
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BACKGROUND AND PURPOSE Excessive daytime sleepiness and sudden sleep attacks are the main features of narcolepsy, but rapid-eye-movement sleep behavior disorder (RBD), hyposmia, and depression can also occur. The latter symptoms are nonmotor features in idiopathic Parkinson's disease (IPD). In the present study, IPD-proven diagnostic tools were tested to determine whether they are also applicab...
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Relatively frequent pituitary hormone deficiencies are observed after traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) and according to the published studies the neuroendocrine consequenses of traumatic brain injury are underdiagnosed. In a cohort of 59 patients (49 males, mean age 68.3 years, 36-88 years) after evacuation of subdural hematoma (SDH) were evaluated hypothalamo-pitu...
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This study aimed to investigate the amygdala’s involvement in dream affect. The amygdala is well known in the literature for its role in emotional processing, especially fear and anger. The amygdala is thought to modulate dream content in REM (rapid eye movement) sleep and is thought to account for large proportion of negative emotion in dreaming, as it is heightened during REM sleep. Patients ...
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Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses of the body become overwhelmed and are no longer able to detoxify reactive oxygen species (ROS). The ROS can then go unchallenged and are able to cause oxidative damage to cellular lipids, DNA and proteins, which wi...
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ژورنال
عنوان ژورنال: Sleep
سال: 2009
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/32.5.607